Labeling of Hyaluronic Acids with a Rhenium-Tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging

Lucas Henry (1) , Nicolas Delsuc (1) , Cécile Laugel (2) , François Lambert (1) , Christophe Sandt (3) , Sarah Hostachy (4) , Anne-Sophie Bernard (1) , Hélène Bertrand , Laurence Grimaud (5) , Arlette Baillet-Guffroy (2) , Clotilde Policar (1)

1 LBM UMR 7203 - Laboratoire des biomolécules
2 Lip(Sys)2 - Lipides : systèmes analytiques et biologiques
3 SSOLEIL - Synchrotron SOLEIL
4 LBM-E1 - Peptides, glycoconjugués et métaux en biologie
5 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)

Hyaluronic acids were labeled with a rhenium-tricarbonyl used as single core multimodal probe for imaging and their penetration into human skin biopsies was studied using IR microscopy and fluorescence imaging (labeled SCoMPI). The penetration was shown to be dependent on the molecular weight of the molecule and limited to the upper layer of the skin.

Domains: Inorganic chemistry

Lucas Henry, Nicolas Delsuc, Cécile Laugel, François Lambert, Christophe Sandt, et al.. Labeling of Hyaluronic Acids with a Rhenium-Tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging. Bioconjugate Chemistry, 2018, 29 (4), pp.987-991. ⟨10.1021/acs.bioconjchem.7b00825⟩. ⟨hal-02009811⟩