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Lysophosphatidyl-choline 16:0 mediates persistent joint pain through Acid-Sensing Ion Channel 3: preclinical and clinical evidences

Abstract : Rheumatic diseases are often associated to debilitating chronic joint pain, which remains difficult to treat and requires new therapeutic strategies. Here, we describe increased content of lysophosphatidyl-choline (LPC) 16:0 in the knee synovial fluids of two independent cohorts of patients with painful joint diseases. If LPC16:0 levels correlated with pain in patients with osteoarthritis (OA), they do not appear to be the hallmark of a particular joint disease. We found that intra-articular injections of LPC16:0 in mouse produce chronic pain and anxiety-like behaviors in both males and females with no apparent inflammation, peripheral nerve sprouting and damage, nor bone alterations. LPC16:0-induced persistent pain state is dependent on peripheral Acid-Sensing Ion Channel 3 (ASIC3), ultimately leading to central sensitization. LPC16:0 and ASIC3 thus appear as key players of chronic joint pain with potential implications in OA and possibly across others rheumatic diseases.
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https://hal.archives-ouvertes.fr/hal-03187657
Contributor : Emmanuel Deval Connect in order to contact the contributor
Submitted on : Thursday, November 25, 2021 - 6:08:41 PM
Last modification on : Tuesday, January 4, 2022 - 6:39:40 AM

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2021.03.29.437487v3.ful.pdf
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Florian Jacquot, Spiro Khoury, Bonnie Labrum, Kevin Delanoe, Ludivine Pidoux, et al.. Lysophosphatidyl-choline 16:0 mediates persistent joint pain through Acid-Sensing Ion Channel 3: preclinical and clinical evidences. 2021. ⟨hal-03187657⟩

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