In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ- Lactam Resistance Phenotypes - INRA - Institut national de la recherche agronomique Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2018

In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ- Lactam Resistance Phenotypes

Résumé

The study evaluated the in vitro activity of ceftolozane-tazobactam (C/T) against 94 unique clinical isolates of Enterobacter cloacae complex (ECC). No difference was observed according to the ECC cluster. The in vitro activity greatly varied depending on the þ-lactamase-producing profile: 100%, 67%, and 19% of wild-type, extended- spectrum þ-lactamase (ESBL)-producing, and AmpC-overproducing strains, respectively, were susceptible to C/T. The use of C/T could be of interest for the treatment of some infections caused by ESBL-producing AmpCnonoverexpressing ECC isolates.

Domaines

Psychologie
Fichier principal
Vignette du fichier
In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ-Lactam Resistance Phenotypes (fait).pdf (236.84 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02313665 , version 2 (20-09-2018)
hal-02313665 , version 1 (11-10-2019)

Identifiants

Citer

Frédéric Robin, Michel Auzou, Richard Bonnet, Romain Lebreuilly, Christophe Isnard, et al.. In Vitro Activity of Ceftolozane-Tazobactam against Enterobacter cloacae Complex Clinical Isolates with Different þ- Lactam Resistance Phenotypes. Antimicrobial Agents and Chemotherapy, 2018, 62 (9), ⟨10.1128/AAC.00675-18⟩. ⟨hal-02313665v1⟩
308 Consultations
237 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More