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Les réarrangements moléculaires : cibles thérapeutiques en cancérologie thoracique

Abstract : Five to ten percent of lung adenocarcinoma harbor chromosomal rearrangements affecting the ALK, ROS1, NTRK and RET genes. These rearrangements are associated with the production of fusion transcripts that lead to the synthesis of chimeric proteins with constitutive kinase activity. These abnormal proteins induce an oncogenic dependency that may be targeted by tyrosine kinase inhibitors. In this review, we will summarize the clinical and molecular epidemiology of chromosomal rearrangements affecting ALK, ROS1, NTRK and RET genes. We will describe the mechanisms of resistance to tyrosine kinase inhibitors that have been reported. We will present the molecular techniques that can be used to detect these rearrangements and the strategies set-up by the molecular oncology laboratories to diagnose these genetic alterations.
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Submitted on : Wednesday, September 21, 2022 - 10:35:41 AM
Last modification on : Tuesday, October 18, 2022 - 4:31:18 AM


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Audrey Mansuet-Lupo, Simon Garinet, Diane Damotte, Marco Alifano, Hélène Blons, et al.. Les réarrangements moléculaires : cibles thérapeutiques en cancérologie thoracique. Bulletin du Cancer, 2020, 107, pp.896 - 903. ⟨10.1016/j.bulcan.2020.05.008⟩. ⟨hal-03491246⟩



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